Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · Ferrostatin-1 (Fer-1) was identified as a ferroptosis inhibitor by Dixon et al. in 2012, which was proved to inhibit RSL3 or erastin induced ferroptosis in HT-1080 cells.
Ferroptosis inhibitors: past, present and future - Frontiers
2024年5月6日 · Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年12月1日 · In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and …
Targeting ferroptosis opens new avenues for the development of …
2023年9月21日 · With respect to cancer, novel ferroptosis agonists have shown promise in several cancer types. On the other hand, antagonists of ferroptosis have been shown to help alleviate...
Ferroptosis: past, present and future - Cell Death & Disease
2020年2月3日 · The application of the ferroptosis inhibitor Fer-1 significantly reduces iron deposition, neuronal degeneration, and injury and improves the prognosis of patients, thus providing an...
Recent progress in ferroptosis: inducers and inhibitors
2022年12月29日 · This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application.
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
2023年9月26日 · In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and …
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and potential for in vivo use is provided.
Ferroptosis inhibitors: past, present and future - PubMed
2024年5月23日 · Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of …
Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic antioxidants.