2020年2月3日 · Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. Activating or blocking the ferroptosis pathway to alleviate the progression of the disease, which...

2021年1月25日 · In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumour...

In this Review, we seek to provide an extensive and critical analysis of the current understanding of the molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumor suppression and immune surveillance, and its pathological roles and potential for therapeutics.

2024年6月6日 · Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and subsequent plasma membrane rupture.

Ferroptosis (also known as oxytosis) is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. Ferroptosis is biochemically, genetically, and morphologically distinct from other forms of regulated cell …

2024年11月21日 · Ferroptosis is a form of cell death driven by irondependent damage to lipids, the building blocks of cellular membranes. Specifically, lipids that contain polyunsaturated fatty acids readily undergo oxidation, causing damage to membranes.

In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumour suppression and immune surveillance, and its pathological roles, together with …

2024年1月24日 · Ferroptosis is involved in the development of a variety of diseases, such as neurological disorders, tissue ischemia-reperfusion injury, and cancer. Ferroptosis has a dual effect on promoting and...

2024年5月30日 · Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to ruptu …

In this review, we first elucidate core mechanisms of ferroptosis and summarize its epigenetic modifications (e.g., histone modifications, DNA methylation, noncoding RNAs, and N6‐methyladenosine modification) and nonepigenetic modifications (e.g., genetic mutations, transcriptional regulation, and posttranslational modifications).