In this review, we present a concise, yet comprehensive summary of both morphological and immunophenotypical variants of plasma cell neoplasms from the archives of MD Anderson Hematopathology Department, with emphasis on possible diagnostic pitfalls precluding a timely and accurate assessment.

2022年2月1日 · Plasma cell neoplasms are notorious for having diverse morphological presentations, and less frequently, unusual immunophenotypical profiles. This unexpected immunomorphological variability could lead to erroneous impressions upon initial assessment, potentially delaying the generation of a final accurate diagnosis.

we are describing different morphological presentation of myeloma where plasma cells showed atypical morphology, leading to varied differential diagnosis. However clinical features with immunophenotyping (IPT) by flowcytometry / immunohistochemistry(IHC) in adjunct to serum electrophoresis, immunofixation and free light chain assays confirmed ...

2023年9月4日 · Here, the authors report seven plasma cell neoplasm cases with unusual morphology, immunophenotype, or unusual anatomic locations from the archives of Montefiore Medical Center Hematopathology department to highlight key considerations involved in diagnosing plasma cell neoplasms.

2015年1月1日 · This chapter describes the role of light microscopy to evaluate intra- and extraosseus plasma cell neoplasms. Characteristic morphologic findings are described, as well as how the findings are used for interpretation and final classification of the plasma cell...

In this review, we present a concise, yet comprehensive summary of both morphological and immunophenotypical variants of plasma cell neoplasms from the archives of MD Anderson Hematopathology Department, with emphasis on possible diagnostic pitfalls precluding a timely and accurate assessment.

2016年12月31日 · Plasma cell myeloma (PCM) is a bone marrow-based neoplasm, the diagnosis of which is straightforward in most cases. The presence of marked cytologic pleomorphism and extramedullary involvement, for example, can make the diagnosis of …

2020年3月29日 · There are several morphological variants of malignant plasma cells, ranging from mature plasma cell morphology, immature plasmablastic morphology, small lymphoplasmacytic morphology, to large anaplastic morphology. Plasma cell quantification in bone marrow samples is important in the diagnosis and discrimination of …

Objective: To investigate the architectural and cytological variations of plasma cell neoplasms, and discuss the diagnosis and differential diagnosis. Methods: Histological and immunohistochemical examinations were used to study the morphologic and immunophenotypic features of 46 cases of plasma cell neoplasms.

2021年7月8日 · This unique morphology of plasma cells, which included anisocytosis, irregular nuclear shape, and cytoplasmic vacuoles, can be seen in progressive disease and may be related to poor prognosis. This unique morphology can be mistaken for a myeloid neoplasm in the aspirate or a non-Hodgkin lymphoma in a biopsy and warrants ancillary testing to ...