Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC 1.14.13.148) that in humans is encoded by the FMO3 gene.

Dimethylaniline Monooxygenase In subject area: Medicine and Dentistry Trimethylaminuria is characterized by FMO3 deficiency, which results in accumulation of TMA in the body and its excretion in urine, breath, and sweat.

含黄素单加氧酶 (FMO) 是一类重要的药物代谢酶，可催化各种含氮、硫和磷的异生素 (如治疗药物、膳食化合物、杀虫剂和其他外来化合物) 的 NADPH 依赖性氧化作用.人类 FMO 基因家族由 5 个基因和多个假基因组成。 FMO 成员具有不同的发育和组织特异性表达模式。 FMO3 基因是成人肝脏中表达的主要 FMO，其表达在个体之间最多可有 20 倍的差异。 FMO3 表达水平的这种个体间差异可能对异生素的代谢率有显着影响，因此对制药行业具有相当大的兴趣。 这种跨膜蛋白 …

2007年1月23日 · Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed: 9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.

2013年1月14日 · Sadeque, A.J.M.; Thummel, K.E.; Rettie, A.E.: Purification of macacque liver flavin-containing monooxygenase: A form of the enzyme related immunochemically to an isoenzyme expressed selectively in adult human liver.

Dimethylaniline Monooxygenase In subject area: Pharmacology, Toxicology and Pharmaceutical Science The flavin-containing monooxygenase (FMO) is a family of enzymes that like the cytochrome P450 (CYP) superfamily evolved during plant–animal warfare to metabolize a plethora of xenobiotics.

2013年1月14日 · Protein target information for Dimethylaniline monooxygenase [N-oxide-forming] 3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds.

1999年1月10日 · The microsomal flavin-containing monooxygenase was known for a number of years as an amine oxidase but was subsequently shown to be also a sulfur oxidase and a phosphorous oxidase. Like CYP, the FMO is a microsomal enzyme, a monooxygenase requiring NADPH and oxygen, and exists as multiple isoforms in various tissues.

摘要： EC number 1.14.13.8 Systematic name N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming) Recommended name dimethylaniline monooxygenase (N-oxide-forming) Synonyms DMA oxidase FAD-containing monooxygenase FMO FMO 1A1 FMO 1B1 FMO 1C1 FMO 1D1 FMO 1El FMO-I FMO-II FMO1 FMO2 FMO3 FMO5 N,N-dimethylaniline monooxygenase dimethylaniline N-oxidase dimethylaniline oxidase flavin ...