2018年1月29日 · Here we focused on the biosynthesis of cysteine, an amino acid that plays an important role in metabolism, as well as modern protein structure and function. As a single molecule, cysteine is...

2011年6月1日 · L-Cysteine biosynthesis in serovar Typhimurium and E. coli ceases almost entirely when cells are grown on L-cysteine or L-cystine, owing to a combination of end product inhibition of serine transacetylase by L-cysteine and a gene regulatory system known as the cysteine regulon, wherein genes for sulfate assimilation and alkanesulfonate ...

2011年6月1日 · The synthesis of L-cysteine from inorganic sulfur is the predominant mechanism by which reduced sulfur is incorporated into organic compounds. L-cysteineis used for protein and glutathione synthesis and serves as the primary source of reduced sulfur in L-methionine, lipoic acid, thiamin, coenzyme A …

Inhibition of cysteine biosynthesis has been proven to interfere with a pathogen’s ability to fight oxidative stress, infect the host and establish long-term infection .

2017年11月15日 · Nature Communications - tRNA-dependent cysteine biosynthesis is catalyzed by the transsulfursome protein complex. Here, the authors use a multidisciplinary approach to structurally characterize...

2004年6月1日 · Cysteine biosynthesis has been studied for about two decades using whole plants, or excised tissues, cell cultures, and cell‐free extracts. Molecular tools were developed leading to an improved understanding of biosynthetic mechanisms and regulation of …

2024年5月5日 · The de novo cysteine biosynthesis pathway, one of the microbial metabolic pathways, plays a crucial role in pathogenicity and drug resistance. This pathway notably differs from that in humans, thereby representing an unexplored …

2021年6月23日 · The biosynthesis of cysteine is crucial and critically regulated by two enzymes. i.e., serine acetyl transferase (SAT) and O-acetyl serine (thiol) lyase (OAS-TL). A descriptive account on the activity and regulatory mechanism of the enzyme is …

2024年5月5日 · Cysteine biosynthesis is crucial for the growth and pathogenicity of pathogens; thus, it is an attractive target for developing novel antimicrobials. Remarkable progress has been made in identifying potent inhibitors, particularly those targeting OASS, a key enzyme in the de novo cysteine biosynthesispathway.

In plants, cysteine biosynthesis plays a central role in fixing inorganic sulfur from the environment and provides the only metabolic sulfide donor for the generation of methionine, glutathione, phytochelatins, iron-sulfur clusters, vitamin cofactors, and multiple secondary metabolites.