Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins. [4] Because of redundancies in the immune system, many complement disorders are never diagnosed. Some studies …

2023年3月13日 · Complement deficiencies are primary immunodeficiencies that cause various clinical scenarios depending on the specific deficient complement protein. This can include an increased risk of a wide range of infectious and local or …

Complement deficiencies and their diagnosis. Over 50% of people who have a deficiency in complement proteins develop infections. An even higher percentage of individuals with a deficiency in the CP develop autoimmunity, primarily systemic lupus erythematosus (SLE).

If your complement proteins aren’t working as expected, or if you don’t have enough of them (complement deficiency), you’re considered immunocompromised and your body is at risk of infections that can be very serious (sepsis).

Deficiencies in the complement cascade can lead to overwhelming infection and sepsis. In addition to playing an important role in host defense against infection, the complement system is a...

2024年10月20日 · Explore the nuances of complement deficiencies, their genetic basis, diagnostic methods, and ongoing research advancements. Complement deficiencies, a group of immune system disorders, impact an individual’s ability to …

The wide range of clinical manifestations of complement deficiencies reflects the complexity of the complement system. As more individuals are identi?ed with specific complement deficiencies, our understanding of how the complement system functions …

Complement deficiencies are considered to be rare disorders and compromise between 1–10% of all cases of primary immunodeficiency. Complement deficiency is also known as hypocomplementaemia. What causes a complement deficiency? Complement deficiencies are …

Inherited complement deficiencies are associated with increased susceptibility to recurrent, severe infections and autoimmune diseases. Functional and molecular analysis can detect defects in all complement system pathways.

2024年9月1日 · Complement protein C3 is common to all pathways, deficiency of which predisposes patients to severe frequent infections and glomerulonephritis. Deficiencies in factor H and factor I, which regulate the alternative pathway, may lead to hemolytic uremic syndrome.