Snorted, smoked, or injected, cocaine rapidly enters the bloodstream and penetrates the brain. The drug achieves its main immediate psychological effect—the high—by causing a buildup of …

2024年8月22日 · However, cocaine’s most significant impact is on the dopamine transporter (DAT), a protein responsible for removing dopamine from the synapse and recycling it back …

2014年1月1日 · As with other drugs of abuse, cocaine changes the signaling of the endogenous neurotransmitters in the brain. Its effects on the dopamine system have been shown to be …

2024年4月23日 · Generally, dopamine reuptake transporters in the reward circuitry carry dopamine — a neurotransmitter implicated in pleasure and motivation — back into the …

Cocaine and the DAT form a strong interaction that translates into strong effects in the synaptic cleft, brain, and behavior. Disorders of dopaminergic systems such as PD and cocaine …

2024年8月22日 · Cocaine inhibits the reuptake of serotonin, a neurotransmitter involved in mood regulation, sleep, and appetite. By blocking serotonin reuptake, cocaine can lead to increased …

2024年8月7日 · As part of the neurotransmitter sodium symporter family, DAT uses the Na + gradient across cell membranes to transport dopamine against its chemical gradient 2. The …

3 天之前 · Although the intermediary candidates or steps linking cocaine treatment to p38 MAPK activation await identification, it is clear that substrate/ligand modulation of transporter …

2024年8月22日 · At the heart of cocaine’s allure and danger lies its profound impact on the brain’s neurotransmitter systems, particularly its role as a reuptake inhibitor. To understand the …

2023年8月4日 · Using cocaine can cause changes to the brain, such as in the reward system, resulting in a buildup of dopamine and making it difficult for someone to stop using the …