Direct access to chiral aliphatic amines by catalytic ... - Nature
2023年3月16日 · Chiral aliphatic amines are privileged functionalities in pharmaceutical molecules and play an essential role as ligands and catalysts in organic synthesis. It is therefore …
Recent Advances in the Enantioselective Synthesis of Chiral Amines …
2021年10月22日 · Using the axially chiral ligand (S)-SegPhos L9b, up to 13 examples of chiral five-membered exocyclic amines P34 were obtained in moderate to high yields and excellent …
Amine dehydrogenases: Current status and potential value for chiral ...
2022年6月16日 · Chiral amines are crucial precursors of various pharmaceutical drugs, fine chemicals, and bioactive molecules. Amine dehydrogenases (AmDHs) have attracted …
Application of Imine Reductase in Bioactive Chiral Amine Synthesis
2024年7月11日 · Nitrogen-containing compounds, especially those with chiral amine structures, play a pivotal role in the field of organic active pharmaceutical ingredients. Traditional …
Chiral Primary Amine-Catalyzed Asymmetric Photochemical …
3 天之前 · Utilizing novel chiral diamine-derived pyrroles and primary amines as catalysts, we successfully synthesized a diverse range of triarylmethanes with high yields and excellent …
Enantioconvergent Cu-catalysed N -alkylation of aliphatic amines
2023年3月20日 · Here we report the use of chiral tridentate anionic ligands to enable the copper-catalysed chemoselective and enantioconvergent N -alkylation of aliphatic amines with α …
Enantioselective access to chiral aliphatic amines and ... - Nature
2021年5月13日 · The use of chiral BOX-based ligand enables the direct access of chiral secondary alkyl-substituted amine and alcohol derivatives in good yields with excellent levels …
Asymmetric Synthesis of Amines | Ellman Laboratory - Yale …
More than 80% of all drugs and drug candidates contain amine functionality. Many of these amine-containing compounds are also chiral and can be challenging to prepare. The Ellman …
Biocatalytic Approaches to the Synthesis of Enantiomerically Pure ...
2013年11月26日 · In recent years biocatalysis has presented a useful alternative to classical synthetic approaches for the synthesis of optically active amines, which serve as chiral …
Design, Synthesis and Application of Chiral Spirocyclic Bisindoles ...
3 天之前 · Herein we report the design of a type of chiral spirocyclic bisindole skeletons where the electronically distinct heteroarenes serve as direct anchor for functional sites. Separate …