The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. In this review, we highlight advances in the understanding of Ca2+ signaling in lymphocytes with special emphasis on SOC entry.

2008年12月17日 · In this review, we highlight advances in the understanding of Ca 2+ signaling in lymphocytes with special emphasis on SOC entry. We also discuss outstanding questions and probable future...

Calcium acts as a second messenger in many cell types, including lymphocytes. Resting lymphocytes maintain a low concentration of Ca 2+. However, engagement of antigen receptors induces calcium influx from the extracellular space by several routes. A chief mechanism of Ca 2+ entry in lymphocytes is through store-operated calcium (SOC) channels.

2019年1月8日 · In this article, we review the expression and function of various Ca 2+ -permeable channels in the plasma membrane, endoplasmic reticulum, mitochondria and endolysosomes of T cells and their role...

2007年8月17日 · Calcium-release-activated calcium (CRAC) channels are the main source of Ca 2+ influx in many cells of the immune system and they are essential for T-cell activation and expression of...

Calcium (Ca 2+) is an essential signaling molecule that controls a wide range of biological functions. In the immune system, calcium signals play a central role in a variety of cellular functions such as proliferation, differentiation, apoptosis, and numerous gene transcriptions.

2007年12月14日 · Calcium ions (Ca 2+) impact nearly every aspect of cellular life. This review examines the principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the mechanisms that control Ca 2+ levels in the cytoplasm and organelles.

The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. In this review, we highlight advances in the understanding of Ca2+ signaling in lymphocytes with special emphasis on SOC entry.

2014年1月1日 · Calcium (Ca 2+) is an important cation able to function as a second messenger in different cells of the immune system, particularly in B and T lymphocytes, macrophages, and mastocytes, among others. Recent discoveries related to the entry of Ca 2+ through the store-operated calcium entry (SOCE) have opened a new investigation area about the ...

2009年9月10日 · Ca 2+ signaling is well established as essential for immune function (1-5). In cells of the peripheral immune system (the focus of this Immunological Reviews volume), Ca 2+ entry is required for short term processes that occur on the time scale of minutes as well as for longer term processes that involve new gene transcription and require hours ...