Purpose: Angiogenesis is known to be essential for the progression of hepatocellular carcinoma (HCC). However, the relationship between the occurrence of HCC and angiogenesis has been not elucidated. CD34 have been used for the detection of active angiogenesis in …

2000年11月10日 · Distinguishing well differentiated hepatocellular carcinoma (HCC) from benign hepatocellular lesions is a well recognized problem in fine-needle aspiration (FNA) cytology. The endothelial cell marker CD34 is negative in normal hepatic sinusoids and stains vessels diffusely in …

2000年10月25日 · The endothelial cell marker CD34 is negative in normal hepatic sinusoids and stains vessels diffusely in HCC. This feature is useful in distinguishing benign from malignant hepatocytic lesions in histological specimens, although benign lesions may show focal positivity for CD34 confined to periportal and periseptal areas.

The complete CD34 staining pattern was seen in virtually all cases of HCC and in only some cases of HA and FNH. The incomplete CD34 staining pattern was characterized by either CD34 positivity in virtually all sinusoidal spaces in some but not all nodules or CD34 positivity in the peripheral sinusoidal spaces adjacent to portal triads.

2024年12月12日 · Tumor associated senescent endothelial cells are frequently observed in both intrahepatic cholangiocarcinoma and combined hepatocellular carcinoma-cholangiocarcinoma, and their presence is significantly correlated with a short survival duration in …

The immunohistochemical expression of CD34 (human hematopoietic stem cell and endothelial cell marker) and laminin were studied in chronic liver diseases and hepatocellular carcinoma (HCC) to elucidate whether their expression reflected phenotypic differences between non-cancerous sinusoids and sinu …

The immunohistochemical markers of hepatocellular carcinoma include those of hepatocellular differentiation—such as hepatocyte paraffin 1 and arginase-1—and those of malignant hepatocytes—such as glypican-3, heat shock protein 70, and glutamine synthetase (GS).

2013年12月1日 · CD34 is one of the most useful immunohistochemical markers in the distinction between benign and malignant hepatocellular lesions. Normal sinusoidal lining cells do not stain for CD34, whereas the abnormal capillaries of HCCs are diffusely CD34 positive.

2013年12月1日 · Our data demonstrate that GPC-3 and CD34 costaining has better diagnostic value for differentiating HCC from nonmalignant hepatocellular lesions than does single staining. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and its prognosis depends largely on early detection and management [1].

The sensitivity and specificity of GPC3 for HCC was 88% and 97%, respectively. There were three CD34 staining patterns observed in hepatic tissue: negative, incomplete positive, and complete positive. In negative staining pattern, only blood vessels in portal triads or rare sinusoidal spaces immediately adjacent to portal tracts were positive.