Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5] [6] [7] [8] PECAM-1 plays a key role …

CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1), is a single chain 130 kDa glycoprotein consisting of 6 Ig-like extracellular domains, a short transmembrane segment and a cytoplasmic tail containing two ITIMs (ImmunoTyrosine Inhibitory Motif).

CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A. 2015;112:E5815–5824. doi: 10.1073/pnas.1509627112. This study builds importantly on the results of reference 65 to demonstrate that PECAM-1 ITIM signaling confers cytoprotection to the vascular endothelium exposed to pro-apoptotic stimuli.

CD31, or PECAM-1 (platelet endothelial adhesion molecule), is a cell-cell adhesion and signaling protein with established roles in immune cell transmigration and angiogenesis.

Breast ductal carcinoma in situ is an intraductal proliferation of malignant epithelial cells that diffuse within the ductal system without stromal invasion. Our finding that a subset of these tumors express CD31/platelet endothelial cell adhesion ...

2024年12月25日 · PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Hemangioma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is FCRL5.

2012年2月29日 · CD31 is a 130 kDa platelet–endothelial cell (EC) adhesion molecule that was initially identified from ECs and platelets 1 and later from blood leucocytes. 2 Mature CD31 contains a short [22-amino acid (aa)] NH 2 -terminal peptide followed by six C2-type immunoglobulin (Ig) domains, each flanked by two conserved cysteine residues outside the cell...

2013年6月1日 · CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a transmembrane homophilic receptor that is expressed by endothelial cells (ECs), platelets, granulocytes, macrophages, dendritic cells (DCs), T- and B-cells and natural killer (NK) cells.

2007年9月13日 · Dangerfield J, Larbi KY, Huang MT, Dewar A, Nourshargh S. PECAM-1 (CD31) homophilic interaction up-regulates α6β1 on transmigrated neutrophils in vivo and plays a functional role in the ability of α6 integrins to mediate leukocyte migration through the perivascular basement membrane.

2002年7月1日 · Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an immunoglobulin–immunoreceptor tyrosine-based inhibitory motif (Ig-ITIM) superfamily member that recruits and activates protein-tyrosine phosphatases, SHP-1 …