As a result of a biochemical reaction, the emission of light by an organism is known as “bioluminescence,” which is a fascinating natural phenomenon of emitting light from living organisms. A bioluminescent system produces light through the oxygenation of a substrate, luciferin, and an enzyme, luciferase.

In this review, we will discuss current trends in bioluminescence and its application in different fields with emphasis on cancer research. Some living organisms are capable of converting chemical energy into light. This natural phenomenon stemmed a research field defined as bioluminescence imaging (BLI).

2024年3月12日 · Bioluminescence, the mesmerizing natural phenomenon where living organisms produce light through chemical reactions, has long captivated scientists and laypersons alike, offering a rich tapestry of insights into biological function, ecology, evolution as well as the underlying chemistry.

2022年9月1日 · Bioluminescent systems can be divided into three types, namely, the luciferin-luciferase (L-L) type, the nonclassical L-L type and the photoprotein type. For L-L system, luciferin emits light by being oxidized in luciferase, and the emitting photons are in proportion to the amount of luciferin.

2020年8月20日 · Bioluminescence has long been used to image biological processes in vivo. This technology features luciferase enzymes and luciferin small molecules that produce visible light. Bioluminescent photons can be detected in tissues and live organisms, enabling sensitive and noninvasive readouts on physiological function.

2024年1月22日 · Here we report optimized versions of the pathway that enhance bioluminescence by one to two orders of magnitude in plant, fungal and mammalian hosts, and enable longitudinal video-rate imaging....

2018年10月15日 · Bioluminescence imaging (BLi) is an established small animal imaging modality for in vivo monitoring of bioluminescent reporter systems 1, 2, 3, 4, 5, 6, 7, 8. BLi is, however, mostly limited...

Therefore, bioluminescence tomography (BLT) has become an important instrument for revealing molecular and cellular signatures that are critically important for numerous biomedical studies. In this chapter, we focus exclusively on bioluminescence tomography.

2023年10月1日 · Combining bioluminescence (BL) with organs-on-chips enables rapid, insitu detection of bioengineered cells, with single-cell resolution. BL detection is compatible with 3D cell-laden hydrogel networks incorporated in organ-on-chip platforms. High signal-to-noise ratio achieved for BL over Fluorescence (FL) when Furimazine substrate is employed.

2025年1月13日 · Explore the science and innovative applications of bioluminescence in genetic engineering, imaging, and research. Bioluminescence is a captivating natural phenomenon where living organisms produce light through biochemical reactions. This ability can be found in various species, from deep-sea creatures to terrestrial fungi.