2021年10月22日 · In 2010, a team from Merck described a general method for the ruthenium-catalyzed AH of trisubstituted N-acyl allyl amines S118 using the axially chiral ligand L49, affording chiral β-substituted amines P118 with excellent enantioselectivities .

2019年6月24日 · From aldehydes to amines: Here, the proof of concept for enzymatic β-chiral secondary amine synthesis via dynamic kinetic resolution (DKR) employing imine reductases is demonstrated. Imine reductases (IREDs) allow the one-step preparation of optically active secondary and tertiary amines by reductive amination of ketones.

2023年4月10日 · In recent years, with the development of various ATA cascades, it has become possible to synthesize chiral amines from a variety of starting materials, thus making them potent catalysts. This review provides an overview of ATAs used in one-pot cascade systems for chiral amine synthesis and classifies cascades based on the starting material.

2021年5月13日 · The use of chiral BOX-based ligand enables the direct access of chiral secondary alkyl-substituted amine and alcohol derivatives in good yields with excellent levels of enantioselectivity ...

2 天之前 · Utilizing novel chiral diamine-derived pyrroles and primary amines as catalysts, we successfully synthesized a diverse range of triarylmethanes with high yields and excellent enantioselectivities. This method not only exhibits a broad substrate scope and outstanding functional group tolerance but also enables the precise synthesis of deuterated ...

Chiral amines bearing a β-methyl stereogenic center are extremely interesting as they are present in numerous drugs and pharmaceuticals. The AH of 2-substituted allyl phthalimides is an efficient route toward their preparation. X.

2023年1月27日 · The progress in biocatalyst development based on α/β hydrolases will promote the biosynthesis of chiral compounds, thus contributing to the green and sustainable development of the chemical and pharmaceutical industry.

2022年7月13日 · Now, an enantioselective Co-catalysed 1,5-C–H amination to form cyclic sulfamidates from alcohols allows for ring opening to deliver diverse β-functionalized chiral amines. Efficient syntheses...

2021年12月3日 · Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmDH), to afford chiral diastereomerically enriched amines in one pot. The asymmetric reduction of unsaturated ketones and aldehydes by ene reductases from the Old Yellow Enzyme family (OYE) was adapted to reaction conditions for ...

2022年6月16日 · As a new biocatalyst, amine dehydrogenases (AmDHs) catalyze the asymmetric formation of chiral amines by ketones. The purpose of this review is to provide a general overview of reported types of natural and engineered AmDHs, their catalytic mechanisms, and the design and application of bioreactors.