Steroid 21-hydroxylase (CYP21A2, P450 21A2) occupies a central position in the biosynthesis of both aldosterone and cortisol. Because circulating aldosterone concentrations are generally …

Like other cytochrome P450 enzymes, steroid 21-hydroxylase participates in the cytochrome P450 catalytic cycle and engages in one-electron transfer with NADPH-P450 reductase. …

2023年7月31日 · 21-hydroxylase deficiency is an autosomal recessive disorder caused by a deficiency in one of the enzymes required for the synthesis of cortisol in the adrenal glands. 21 …

21-Hydroxylase (P450c21) is responsible for conversion of progesterone to deoxycorticosterone (DOC) in the aldosterone biosynthetic pathway (see Fig. 11-9) and 17α-hydroxyprogesterone …

Steroid 21-hydroxylase (P450c21, CYP21) is a microsomal cytochrome P450 enzyme that converts 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to …

2023年8月18日 · Here we review the approach to medication titration for children and adults with classic 21OHD, with an emphasis on how to interpret adrenal biomarker values in guiding this …

Steroid 21 Monooxygenase, also known as 21-Hydroxylase (P450c21), is an enzyme found in the endoplasmic reticulum that plays a crucial role in the 21-hydroxylation of steroids. This …

2020年3月16日 · The side-chain cleavage and the three hydroxylations are mediated by four distinct cytochromes P450. This chapter reviews the biochemistry and molecular biology of …

2018年10月4日 · The steroid 21-hydroxylase (CYP21) enzyme is required for cortisol and aldosterone biosynthesis, and its deficiency is the most common cause of congenital adrenal …

2022年4月12日 · Steroid 21-hydroxylase is an enzyme of the steroid pathway that is involved in the biosynthesis of cortisol and aldosterone by hydroxylation of 17α-hydroxyprogesterone and …