The 3-beta-HSD enzyme allows formation of 17-hydroxyprogesterone (17-OHPG) from 17-hydroxypregnenolone and progesterone from pregnenolone. When 3-beta-HSD is deficient, cortisol is decreased, 17-hydroxypregnenolone and pregnenolone levels may increase, and 17-OHPG and progesterone levels are low.

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline. [1] .

The 3-beta-HSD enzyme allows formation of 17-hydroxyprogesterone (17-OHPG) from 17-hydroxypregnenolone and progesterone from pregnenolone. When 3-beta-HSD is deficient, cortisol is decreased, 17-hydroxypregnenolone and pregnenolone levels may increase, and 17-OHPG and progesterone levels are low.

17 α-羟孕酮，是一种有机化合物，化学式为c 21 h 30 o 3 ，是在合成糖皮质激素和性类固醇过程中产生的一种c-21内源性孕激素，可以在17 α-羟化酶作用下由孕酮转化，或者在3 β-羟类固醇脱氢酶作用下由17 α-羟孕烯醇酮转化，由肾上腺皮质及性腺产生，其孕酮活性 ...

17α-羟孕烯醇酮（英語： 17α-Hydroxypregnenolone ）是一种孕烷类（C21）甾体物质，由孕烯醇酮在C17的α位羟基化而来。 体内的17α-羟孕烯醇酮由 肾上腺 和 生殖腺 的 线粒体 细胞色素P450氧化酶 ——17α-羟化酶（ CYP17A1 ）氧化而来。

17 Hydroxypregnenolone is a compound formed through the conversion of pregnenolone, essential for the production of cortisol and sex hormones. Deficiency in this process leads to decreased secretion of glucocorticoids and sex hormones, along with an increase in mineralocorticoids, resulting in hypertension and hypokalaemia.

17-Alpha-Hydroxypregnenolone is an endogenous steroid hormone synthesized by the hydroxylation of pregnenolone, which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens, and …

17 Hydroxypregnenolone is a compound that is formed by the conversion of pregnenolone catalyzed by the enzyme Steroid 17α-hydroxylase (CYP17). It plays a role in the synthesis of dehydroepiandrosterone and is essential for androgen and estrogen biosynthesis. You might find these chapters and articles relevant to this topic.

Increased levels of 17-hydroxypregnenolone or DHEA are diagnostic of this disorder. Treatment consists of replacement doses of glucocorticoid to suppress ACTH levels and adrenal androgen production. The conversion of pregnenolone to 17-hydroxypregnenolone, progesterone to 17-hydroxyprogesterone, 17-hydroxypregnenolone to DHEA, and 17 ...

17-Hydroxypregnenolone is a steroid hormone produced within the body. The measurement of its levels in the blood serum provides valuable insights into hormonal balance and endocrine function.