Van der Bruggen and colleagues identified the first human tumor antigen, MAGE-1, a cancer/testis antigen (CTA) recognized by endogenous T cells. CTAs are expressed in testes, …

2022年2月14日 · Personalized immunotherapy targeting tumor-specific antigens (TSAs) could generate efficient and safe antitumor immune response without damaging normal tissues. …

2023年7月6日 · The remarkable capacity of immunotherapies to induce durable regression in some patients with metastatic cancer relies heavily on T cell recognition of tumor-presented …

Here, we discuss molecular identification of different tumor antigen types, and the clinical safety and efficacy of targeting them with immunotherapy. Additionally, we suggest strategies to …

2021年3月9日 · To date, clinically effective CD8 + T cell responses appear to target predominantly antigens derived from tumour-specific mutations that accumulate in cancer, …

2025年1月14日 · Whereas terminally exhausted T (Tex_term) cells retain anti-tumor cytotoxic functions, the frequencies of stem-like progenitor-exhausted T (Tex_prog) cells better reflect …

2023年7月24日 · Detailed characterization of the recognition and activation characteristics of T cells from successful therapy against melanoma unveils that individual T cells recognize …

3 天之前 · CAR-T cells and T cells with an antigen-specific TCR increase their ability to donate molecules to other T cells when challenged with tumor cells expressing the cognate antigen. …

2020年10月12日 · Identification of specific tumor antigens, as well as T cells that recognize them, is essential for the design and execution of both vaccine- and ACT-based immunotherapy …

2024年12月10日 · CAR T-cell therapy is an FDA-approved therapy that has improved progression-free survival for multiple myeloma, improved overall survival for large B-cell …