The shikimate pathway (shikimic acid pathway) is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for the biosynthesis of folates and aromatic amino acids (tryptophan, phenylalanine, and tyrosine). This pathway is not found in …

The shikimate or shikimic acid pathway is concerned with the production most of the phenolics in bacteria, fungi and plants by converting the simple carbohydrate molecules (resulting from pentose phosphate pathway and glycolysis) into phenylalanine and tryptophan. From: Biotechnology Reports, 2019

The shikimate pathway, named after shikimic acid as important intermediate, is a seven-step metabolic route used by bacteria, fungi, algae, parasites, and plants for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

2019年1月31日 · The shikimate pathway consists of seven reaction steps, beginning with an aldol-type condensation of phosphoenolpyruvic acid (PEP) from the glycolytic pathway, and D-erythrose-4-phosphate, from the pentose phosphate cycle, to produce 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP).

The shikimate pathway or pathway of cyclohexenecarboxylic acid displayed in Fig. 2 is widely distributed in microorganisms and plants where shikimic acid is a precursor for the biosynthesis of primary metabolites such as aromatic amino acids and folic acid and a …

2024年4月24日 · Seven metabolic steps convert phosphoenolpyruvate (PEP) and erythrose 4-phosphate (E4P) into shikimate and ultimately chorismate, which serves as the branch point for dedicated aromatic amino acid biosynthesis.

This comparative bioinformatics analysis of genes of the shikimic acid pathway in prokaryotes provides essential details that should help guide the choice of key organisms for future studies designed to reveal new metabolic processes in shikimic acid biosynthesis or to validate the loss of key biosynthetic genes.

2024年9月8日 · The Shikimic Acid Pathway is an essential metabolic route in plants, fungi, and some bacteria, leading to the synthesis of aromatic amino acids and a diverse range of secondary metabolites.

The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites.

This review focuses on the seven enzymes of the shikimate pathway, highlighting their primary sequences, functions and three-dimensional structures. The understanding of their active site amino acid maps, functions and three-dimensional structures will provide a framework on which the rational design of antimicrobial drugs would be based.