What is cytokine release syndrome? Cytokine release syndrome (CRS) — sometimes called cytokine storm or cytokine-associated toxicity — is a condition that develops when your immune system responds too aggressively to infection. It can also happen after certain types of immunotherapy, such as CAR T-Cell Therapy.

2024年4月2日 · Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction. CRS is most often associated with chimeric antigen receptor (CAR)-T cell therapy, but it also occurs in association with bispecific T cell engager therapy, other monoclonal antibody-based therapy, haploidentical ...

In immunology, cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. [3]

2024年5月2日 · Cytokine release syndrome occurs when many cytokines flood the body at once, often after an infusion or injection of antibodies. This sends the body’s immune system into overdrive, prompting an inflammatory response.

2022年10月5日 · What is cytokine release syndrome? Cytokine release syndrome is a set of symptoms that can develop as a side effect of immunotherapy treatment or as a response to infection....

Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by a variety of factors such as infections and certain drugs. The term “cytokine release syndrome” was first coined in the early ‘90s, when the anti-T-cell antibody muromonab-CD3 (OKT3) [ 1 , 2 ] was introduced into the clinic as an immunosuppressive ...

2022年2月7日 · Cytokine release syndrome (CRS) is caused by a rapid and mild to massive release of cytokines from immune cells involved in immune reactions, particularly after immunotherapy.

2020年6月11日 · Cytokine release syndrome (CRS) occurs due to high levels of inflammation in the body. Find out about the symptoms of CRS and how it links to COVID-19 here.

2024年6月19日 · What Is Cytokine Release Syndrome (CRS)? Cytokine release syndrome (CRS) is a condition that occurs when the immune system is highly activated, leading to the rapid and excessive release of cytokines into the bloodstream. Cytokines are small proteins that play a crucial role in regulating immune responses and inflammation.

2025年1月17日 · Abstract. Cytokine release syndrome (CRS) is a common acute toxicity in T-cell therapies, including T-cell–engaging bispecific antibodies (T-BiSp). Effective CRS management and prevention are crucial in T-BiSp development. Required hospitalization for seven of the nine approved T-BiSp and the need for clinical intervention in severe cases highlight the …