2025年1月16日 · Latest news New Insights Into Why Huntington’s Disease Has Delayed Onset. A highly-anticipated scientific paper has landed! This new work challenges current theories in Huntington’s disease research, uncovering how runaway CAG repeats erode cell identity in certain types of brain cells, leading to their death.

2024年12月10日 · Latest news Beta-blockers associated with delayed onset and decreased progression of Huntington’s disease. A well-studied, widely used class of drugs for heart health may have benefits for Huntington’s disease.

3 天之前 · Glossary; Total Functional Capacity A standardized rating scale for function in HD, used to assess capacity to work, handle finances, perform domestic chores and self-care tasks ; NfL biomarker of brain health ; huntingtin protein The protein produced by the HD gene.; clinical trial Very carefully planned experiments designed to answer specific questions about how a drug affects human beings

Mini brains grown in a dish shed light on Huntington’s disease and how we might treat it. Exciting new findings using 3D human lab-grown mini brains inform ongoing HTT-lowering trials and suggest that stem cell transplants for HD may improve cell-to-cell communication and reduce disease features.

2025年1月17日 · Glossary; NfL biomarker of brain health ; huntingtin protein The protein produced by the HD gene.; clinical trial Very carefully planned experiments designed to answer specific questions about how a drug affects human beings ; inflammation Activation of the immune system, thought to be involved in the HD disease process ; CAG repeat The stretch of DNA at the beginning of the HD gene, which ...

2025年1月20日 · Glossary; blood-brain barrier A natural barrier, made from reinforcements to blood vessels, that prevents many chemicals from getting into the brain from the bloodstream ; CAG repeat The stretch of DNA at the beginning of the HD gene, which contains the sequence CAG repeated many times, and is abnormally long in people who will develop HD ; aggregate Lumps of protein that form inside cells in ...

2024年5月1日 · HDBuzz strives to be an honest and neutral source of information that Huntington’s disease (HD) families can turn to for trusted, unbiased reporting on research and clinical trial news. We’re honored to have become a global resource for the HD community over the years (14!) and we look forward to building upon the original mission of …

2025年1月2日 · As we wave goodbye to 2024, the HDBuzz team reflects on a year marked by significant progress, challenges, and hope. From breakthroughs at the lab bench, advancements in drug development, and both road bumps and triumphs in clinical trials, we have gained new insights into the workings of Huntington’s disease (HD), and made great strides towards finding medicines which might slow or halt ...

2025年1月13日 · Glossary; ASOs A type of gene silencing treatment in which specially designed DNA molecules are used to switch off a gene ; neurodegenerative A disease caused by progressive malfunctioning and death of brain cells (neurons) ; transcription the first step in making a protein from the recipe stored in a gene. Transcription means making a working copy of the gene from RNA, a chemical messenger ...

2024年12月10日 · Glossary; Total Functional Capacity A standardized rating scale for function in HD, used to assess capacity to work, handle finances, perform domestic chores and self-care tasks ; NfL biomarker of brain health ; huntingtin protein The protein produced by the HD gene.; clinical trial Very carefully planned experiments designed to answer specific questions about how a drug affects human beings