2024年9月11日 · Once RNA Pol II engages with the PIC, TFIIH is recruited by contacting mediator and RNA Pol II 39,40 and its CDK7 component phosphorylates the C-terminal …

2022年10月6日 · CBP stabilizes RNA polymerase II (Pol II) at PcG-bound repressive sites and promotes Pol II pausing independently of its histone acetyltransferase activity. CBP and Pol II …

by promoting RNA Pol II pausing d Pol II pausing establishes R-loops and open chromatin to sustain PcG occupancy d p300/CBP catalytic activity is dispensable for Pol II pausing and …

2022年10月6日 · Polycomb group (PcG) proteins induce chromatin compaction but require access to DNA for maintenance of long-term gene silencing. Hunt et al. show that p300/CBP …

2012年1月27日 · Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. ... (Pol II), and mRNA production. Ezh1 …

Many developmental control genes contain paused RNA polymerase II (Pol II) and are thereby “poised” for rapid and synchronous activation in the early Drosophila embryo. Evidence is …

多梳蛋白抑制复合物（Polycomb repressive complexes，PRC）能在染色质层面进行调控基因表达，是发育过程中不可缺少的一环。在哺乳动物中，PRC能够靶向识别基因组中的特定位点，通 …

2024年6月19日 · Pol II 降解后上调基因特征分析发现Polycomb 结合的、较少转录暂停的短基因表达增加。这些上调的基因在参与 GPCR 配体结合的功能类别中富集。接下来，研究发现， …

2022年10月6日 · CBP and Pol II pausing are necessary for RNA-DNA hybrid (R-loop) formation and nucleosome depletion at Polycomb Response Elements (PREs), whereas transcription …

2012年12月27日 · In contrast, Polycomb group repression is tissue specific, and in combination with Pol II (the balanced state) marks genes with highly dynamic expression. This suggests …