GABA transporter - Wikipedia
GABA transporters in the plasma membrane help in regulating the concentration of GABA in the extracellular matrix by reabsorbing the transmitter and clearing the synapse. They transiently bind to GABA in the extracellular matrix and translocate the transmitter in the cytoplasm.
GABA transport cycle: beyond a GAT feeling - Nature
2023年7月3日 · Four GABA transporter (GAT) subtypes, GAT1, GAT2, GAT3 and betaine/GABA transporter 1 (BGT1), are the key regulators of inhibitory neurotransmission through cellular uptake of GABA from the...
Structure, function, and plasticity of GABA transporters
2014年6月16日 · Here we review the current knowledge on the structural and functional properties of GABA transporters and highlight the molecular mechanisms that alter the expression and mobility of GABA transporters at central synapses. The brain utilizes GABAergic synaptic transmission to modulate the ongoing activity of neuronal networks.
Structural basis of GABA reuptake inhibition - Nature
2022年6月8日 · γ-Aminobutyric acid (GABA) transporter 1 (GAT1) 1 regulates neuronal excitation of the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter GABA upon its...
Molecular basis for substrate recognition and transport of human GABA …
2023年7月3日 · GAT1, which is mainly expressed in the presynaptic terminals of axons, is a potential drug target of neurological disorders due to its essential role in GABA transport. Here we report four...
Localization and Function of GABA Transporters GAT-1 and GAT-3 …
GABA transporter type 1 and 3 (GAT-1 and GAT-3, respectively) are the two main subtypes of GATs responsible for the regulation of extracellular GABA levels in the central nervous system.
GABA Transporter - an overview | ScienceDirect Topics
GABA Transporters, in the context of neuroscience, refer to electrogenic transporters that facilitate the symport of GABA along with Na+ and Cl- ions across the plasma membranes of GABAergic neurons and astroglia.
GABA Transporter - an overview | ScienceDirect Topics
The GABA transporter is a symport carrier that couples the transport of two Na+, one Cl−, and one GABA molecule into the cell. From: Foundations of Anesthesia (Second Edition), 2006
Regulation of Glutamate, GABA and Dopamine Transporter …
Here we discuss recent advances in the mechanisms that control the cell membrane trafficking and biophysical properties of transporters for the excitatory, inhibitory and modulatory neurotransmitters glutamate, GABA, and dopamine. Keywords: glutamate, GABA, dopamine, transporter, uptake, surface mobility.
Localization and Function of GABA Transporters GAT-1 and GAT-3 …
2011年7月28日 · GABA transporter type 1 and 3 (GAT-1 and GAT-3, respectively) are the two main subtypes of GATs responsible for the regulation of extracellular GABA levels in the central nervous system.
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