Cathinone (/ ˈ k æ θ ɪ n oʊ n /; also known as β-ketoamphetamine) is a monoamine alkaloid found in the shrub Catha edulis and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to the stimulant effect of …

Similar to amphetamines, synthetic cathinones are psychomotor stimulants that exert their effects by impairing the normal function of plasma membrane transporters for dopamine (DAT), norepinephrine (NET), and 5-HT (SERT).

Cathinone is a close structural relative of amphetamine. Today, certain cathinone derivatives, synthetic cathinones, are known to produce central stimulant actions and represent a “new” class of drugs of abuse.

Synthetic cathinones, derived from cathinone found in the plant Catha edulis, represent the second largest and most frequently seized group of new psychoactive substances. They are considered as β-keto analogs of amphetamine, sharing pharmacological effects with amphetamine and cocaine.

Cathinone is a naturally occurring stimulant found in the leaves of the Khat plant (Catha edulis). Synthetic derivatives of cathinone emerged as drugs of abuse in approximately 2003 and were sold as “Bath Salts” and labeled as “not for human consumption.”

CB1 receptors are amongst the most abundant GPCRs in the central nervous system, although they are also present in the peripheral nervous system (Di Marzo, Bifulco, & Petrocellis, 2004). CB2 receptors are mostly present on immune tissues and immune cells, but are also moderately expressed in specific brain areas.

2018年4月17日 · Pharmacological targets of cathinone psychostimulants are dopamine , serotonin , and noradrenaline re-uptake transporters (DAT , SERT , and NET , respectively), as well as monoamine receptors. However, there are considerable differences among cathinones with respect to potencies and relative activity at monoaminergic targets.

2012年12月20日 · We determined the potencies of cathinones to inhibit DA, NA and 5-HT transport into transporter-transfected HEK 293 cells, DA and 5-HT efflux from monoamine-preloaded cells, and monoamine receptor binding affinity. Mephedrone, methylone, ethylone, butylone and naphyrone acted as non-selective monoamine uptake inhibitors, similar to cocaine.

2018年4月17日 · Like amphetamines, cathinones exert their stimulant effects via increasing synaptic concentrations of dopamine (DA), noradrenaline (NA), and serotonin (5-HT), albeit at various potencies. These compounds interact with plasma membrane transporters for …

Cathinone, the principal active ingredient in the leaves of the khat plant (catha edulis), can be considered as the prototype from which a range of synthetic cathinones have been developed. Internationally controlled substances in this group are cathinone, methcathinone, cathine and …