• Histology is mandatory in assessing cardiac hypertrophy, especially to confirm or exclude storage and infiltrative myocardial disorders. Extensive myocardial disarray is typically observed in hypertrophic cardiomyopathy.

Microscopically, severity of myocyte hypertrophy appears to be associated with the presence of recognized HC cardiac myofilament mutations (P = .03). Other histologic features characteristic of HC were not consistently associated with myofilament mutation status.

2024年6月7日 · Hypertrophic cardiomyopathy (HCM) is an autosomal dominant cardiac myocyte disease caused by mutations in sarcomere and sarcomere-related protein genes encoding for elements of the contractile machinery of the heart.

‘Pathological’ cardiac hypertrophy is a condition that is characterized by the thickening of the heart muscle, a decrease in the size of the chambers of the heart, and a reduced capacity of the heart to pump blood to the tissues and organs around the body.

2021年5月1日 · Original Investigation: Myocardial Histopathology in Patients With Obstructive Hypertrophic Cardiomyopathy. Over the past 65 years, substantial advances have been made in our understanding and treatment of hypertrophic cardiomyopathy (HCM).

2021年3月19日 · • Histology is mandatory in assessing cardiac hypertrophy, especially to confirm or exclude storage and infiltrative myocardial disorders. Extensive myocardial disarray is typically observed in hypertrophic cardiomyopathy.

2016年3月10日 · In this article, we provide an overview of the genetics, pathophysiology, and clinical manifestations of HCM, with the spectrum of imaging findings at MR imaging and CT and their contribution in diagnosis, risk stratification, and therapy. © RSNA, 2016.

2021年5月4日 · Hypertrophic cardiomyopathy (HCM) is characterized by multiple pathological features including myocyte hypertrophy, myocyte disarray, and interstitial fibrosis. This study sought to correlate myocardial histopathology with clinical characteristics of patients with obstructive HCM and post-operative outcomes following septal myectomy.

HCM is an inherited intrinsic disease of the myocardium characterized by left ventricular hypertrophy without chamber dilatation, in the absence of either a systemic or other cardiac disease, which may cause a similar magnitude of hypertrophy.

2016年9月12日 · We assessed the overall amount, apex-to-base, circumferential, epicardial–endocardial distribution, pattern, and type of MF in 30 transplanted hearts of end-stage, hypertrophic cardiomyopathy. Visual and morphometric histological analyses at basal, midventricular, and apical levels were performed.