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Like lecanemab before it, donanemab’s path to market has been slow and rocky. In the U.S., the antibody received Food and ...

Dysfunctional Family. A family tree of tau folds now incorporates two new structures—P301L, P301T (bottom)—and fills in ...

The first evidence that removing amyloid plaques may delay Alzheimer’s symptoms has now been published. In The Lancet Neurology on March 19, scientists led by Randall Bateman at Washington University ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Having a better midlife diet associated with better functional connectivity between the hippocampus and both the occipital ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

In other words, every successive birth cohort has a lower risk of dementia than did its predecessor. Extrapolated forward, these rates would predict only a 25 percent bump in dementia cases by 2050.

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

For years, the Alzheimer’s disease field has been on a quest for the perfect blood marker. Such a test could spare patients from invasive lumbar punctures, broaden care access, and allow AD cases to ...