This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...

Maryland–based biotech NextCure acquired the rights to the CDH6-targeting antibody–drug conjugate (ADC) SIM0505 from Chinese company Simcere Zaiming for up to $745 million in combined upfront and ...

Cancer Res (2024) 84 (6_Supplement): 2547. Introduction: Gene-wide KRAS mutation has been associated with worse outcomes in multiple malignancies with newer data suggesting differential impact based ...

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Introduction: Cxcl10 chemokine signaling has been implicated in cancer cell invasion and metastasis, but the mechanism is not well understood. Our prior studies have shown that deletion of the ING4 ...

Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports ...

In a letter addressed to NIH director Jay Bhattacharya, MD, dubbed the Bethesda Declaration, NIH staff members criticized many of the agency’s actions under the Trump administration. Representing all ...

The abbreviations used are MDM2, human gene and oncogene; MDM2, human protein and isoform; mdm2, mouse gene; Mdm2, mouse protein.

1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Department of Laboratory Medicine, School of Public Health, School of Life Sciences, Xiamen University, ...