J Control Release：携带sirna的新型纳米药物有望治疗HIV感染. 研究开发出一种新型纳米药物，这种药物含有称为小干扰 RNA的遗传物质，以便可以利用基因 ...

A better understanding of the mechanisms of siRNA cellular uptake, intracellular transport and endosomal release could critically contribute to the improvement of delivery methods.

Mechanism For The In-vivo Transport Of SiRNA Date: September 21, 2007 Source: Swiss Federal Institute of Technology Summary: RNA interference, a natural mechanism that inhibits the gene expression ...

文章报道了新型肝脏血管紧张素原靶向siRNA候选药物的临床前开发过程——经生物信息学筛选、化学修饰优化及结合肝脏靶向配体，成功开发出了数 ...

RNA interference, a natural mechanism that inhibits the gene expression of individual genes in eukaryotic cells, is a major topic in modern biology. However, their potential was usable to only a ...

Current efforts are addressed towards understanding the role of proteins and associated RNAs in mechanisms underlying piRNA biogenesis and transposon suppression. Skip to ... Recognition of siRNA by a ...

Thus, in a nutshell, the Tuschl I patent describes RNAi roughly depicting the siRNA mechanism. In contrast, the Tuschl II patent specifically describes the dsRNA molecules of precise size with the ...

China has issued a notification of patent grant to bioAffinity for its novel method of using siRNAs to selectively kill ...

Ago2 and hAgo 2 are the PPD proteins involved in siRNA-mediated silencing in nematodes (C. elegans), arthropoda, and chordata. These proteins are efficient in performing siRNA-mediated m-RNA cleavage.

NHC Key Laboratory of Birth Defect Research and Prevention, MOE Key Laboratory of Rare Pediatric Diseases, Institute of Cytology and Genetics of School of Basic Medical Sciences & Department of ...

Megalin ligand-siRNA conjugates led to significant gene knock-down across multiple targets and was durable for up to 40 days in mice. Judo Bio’s Kidney Week poster presentation is available here ...