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肝细胞癌（HCC）死亡率高，现有诊断和治疗手段存在局限。研究人员聚焦蛋白激酶 DNA 激活催化亚基（PRKDC）开展研究，发现它是可靠预后生物标志物和潜在治疗靶点。这为 HCC 诊疗提供新策略，意义重大。