Phosphorothioate (PS) oligonucleotides have drawn more and more attention lately due to their great therapeutic potential. The presence of one (or several) phosphorothioate moiety (ies) improves ...

To provide a potential approach, the research groups of Weihong Tan and Xue-Qiang Wang at the Hangzhou Institute of Medicine used phosphorothioate backbone modification to enhance the recognition ...

To provide a potential approach, the research groups of Weihong Tan and Xue-Qiang Wang at the Hangzhou Institute of Medicine used phosphorothioate backbone modification to enhance the recognition ...

Achieve narrow peaks and high sensitivity by optimizing the separation of phosphorothioate oligonucleotides in 5 steps using the strong anion exchanger BioPro IEX QF. Publications All Publications ...

We’ve expanded our capabilities with a state-of-the-art, 200,000 sq ft TRC facility in Toronto, completed in 2024 and staffed by over 100 PhD- and MSc-level scientists. This investment enables the ...

However, we lack quantitative understanding of the phosphorothioate DNA (PT-DNA) cleavage efficiency and the chemoselectivity of this method for determination of phosphorothioate vs. phosphate.

Among the vast number of oligonucleotide backbone modifications, phosphorothioate modification is the most widely used in research and the clinic. However, along with their merits are notable ...

The approach combines an oxazaphospholidine method 12 and the direct conversion of a phosphite having a tertiary alcohol into an S-alkyl phosphorothioate via an Arbusov-type mechanism. Using ...

State Key Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China We sought to address these questions in this study, and show ...