DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by sulphur. This covalent change ...

Here, we use a G-quadruplex (thrombin-binding aptamer) and stem/loop structure (dehydroepiandrosterone sulfate binding aptamer) as model cases to show for the first time that the stereochemistry of ...

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Phosphorothioate-modified oligodeoxynucleotide (ASO) were synthesized at BioSune, Shanghai, China. The ASO was introduced into HT29 or HCT116 cells by nucleofection (Lonza) according to the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The gene gp48 from the mycobacteriophage ...

This is an important study that establishes how anti-sense oligonucleotides (ASOs) degrading a specific target protein called EMC10 can rescue neuronal function in models of chromosome 22.11.2 ...