I've spent the last few years looking for my own evidence-based elixir of youth. And there is one common food that could be ...

为探究衰老细胞（SnCs）与腰痛（LBP）关系，研究人员用o-vanillin 和 RG-7112 治疗sparc?/? 小鼠，发现可缓解 LBP。 在人体衰老和受到外界细胞应激时，衰老细胞（SnCs）会在体内不断积累。这些细胞会呈现出衰老相关分泌表型（SASP），释放出各种炎性和退行性因子，进而引发多种与年龄相关的疾病。其中，腰痛（LBP）作为全球导致残疾的首要原因，给个人生活质量和医疗系统都带 ...

Besides classic tobacco and alcohol risk factors, human papillomavirus (HPV) plays a role in the development of a subset of head and neck squamous cell carcinomas (HNSCCs), and notably oropharynx ...

他们揭示了格列本脲这一常见的磺酰脲类降糖药，可通过抑制线粒体苹果酸脱氢酶2（MDH2），显著降低了衰老相关β-半乳糖苷酶（SA-β-gal）染色的阳性率，减轻了衰老相关基因p16INK4a的表达，并缓解了衰老相关分泌表型。 机制上，研究人员发现，抑制或敲除MDH2会 ...

The manuscript presents valuable data suggesting that enalapril elevates pSmad1/5/9 signaling, reduces cellular senescence, and enhances physiological functions in aged mice. However, the in vivo ...

该研究建立了体内细胞衰老的谱系示踪及功能研究技术，开发了四种互补的遗传策略，研究不同细胞类型中p16Ink4a+衰老细胞的体内命运与特定功能。

British Heart Foundation Centre for Research Excellence, School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King’s College London ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...