编辑推荐： 为探究细胞衰老与 tau 病变（MAPTP301S;PS19）的关联，研究人员开展 p16Ink4a相关研究。发现敲除 p16Ink4a可减轻 PS19 小鼠衰老特征、神经炎症等病变，且内皮细胞和小胶质细胞中 p16Ink4a缺失也有类似效果，为疾病机制研究提供新方向。

AbstractBackground:. Our group previously showed that p16INK4a (p16) expression, a biomarker of senescence (a fundamental process of aging), increases after adjuvant breast cancer chemo. However, no ...

Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev 13: 1355-1360.

By measuring levels of p16INK4a, a key marker of cellular aging, the team found significantly higher levels in individuals with SCD. Remarkably, some participants showed biological aging equivalent to ...

Expression of PBTL p16INK4a in AYAs with SCD. (A) Mean p16 expression in AYAs with SCD (10.1 log2 p16 units) is significantly elevated compared to those without SCD (8.7 log2 p16 units), p < 0.001.

消除p16Ink4a+巨噬细胞后，小鼠肝纤维化的免疫微环境发生变化，包括T细胞活化、增殖、分化和参与免疫反应的淋巴细胞活化增强，流式细胞术也观察到T细胞和NK细胞的比例显著增加，它们在肝纤维化的限制和消退中起重要作用，因此，特异性消除p16Ink4a+巨噬细胞可能通过促进T细胞的生长和活化限制了肝纤维化。

It is with great interest that we read the results of Zhuang Li and colleagues’ systematic review and meta-analysis.1 We laud the authors on their stratification of data on the basis of geography, ...

A new research paper titled "Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity" has been ...

因此，防止与年龄相关的p16INK4a表达增加的方法可能对设计促进健康老龄化的干预策略具有重要意义。 研究小组的发现围绕着一种参与RNA编辑的特殊酶：ADAR1——作用于 RNA的腺苷脱氨酶 (ADAR) 是 RNA 编辑酶，也被认为是人类衰老的重要调节因子，ADAR 失活会导致与年龄相关的病理。