Lipopolysaccharide (LPS) induction of the gene encoding interleukin 12 p40 requires remodeling of a promoter-encompassing nucleosome and the Toll-like receptor (TLR)–mediated activation of a c ...

Principles and patterns of nucleosome positioning have emerged through recent advances in genome-wide mapping technologies. These patterns have improved understanding of how DNA sequence and ...

New Tool Predicts Nucleosome Position Institute for Research in Biomedicine (IRB Barcelona) Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living ...

The eukaryotic genome exists in the form of chromatin, with the basic repeating nucleosome subunit a core-histone octamer (two each of H2A, H2B, H3, and H4) wrapped by ~147 base pairs of DNA (Figure ...

Nucleosome Dynamics wrappers for MuGVRE platform ... Python 0 Apache-2.0 0 0 0 Updated on Apr 12, 2019 nucleosome_dynamics_galaxy Public Nucleosome Dynamics wrappers for Galaxy platform ... HTML 0 ...

Maintaining nucleosome proteostasis Across all domains of life, protein quality control is critical for organismal survival. Within organelles such as the mitochondria and endoplasmic reticulum, there ...

The nucleosome consists of a histone octamer (two copies each of H2A, H2B, H3, and H4) with approximately 147 base pairs of DNA wound around it. Histones undergo various post-translational ...

Nucleosomes are dynamic entities with wide‐ranging compositional variations. Human histone variants H2A.B and H2A.Z.2.2 play critical roles in multiple biological processes by forming unstable ...

Figure 1. Profiles for nucleosome occupancy (blue), methylation level (green) and CpG density (pink). For each position in the region the nucleosome occupancy, methylation level and CpG density is ...

We hypothesize that nucleosome remodeling, without remodeler recruitment, may regulate the state of a bound TF. Specifically, a remodeler may attempt to move a nucleosome to or through a site ...

Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic ...

The basic unit of eukaryotic chromatin is the nucleosome, which consists of a histone octamer wrapped around 147 bp of DNA. In yeast, adjacent nucleosomes are connected by ∼20 bp “linkers” such that ...