Scientists are trying to tackle Alzheimer's from all angles, and a new study adds to the growing evidence that semaglutide, a ...

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known ...

University of Washington-led research, published in 2023, discovered microglia in the brains of people with Alzheimer's disease were in a pre-inflammatory state more frequently, making them less ...

Glia are essential for brain functioning during development and in the adult brain. Here, we discuss the various roles of both microglia and astrocytes, and their interactions during brain development ...

Long-read RNA sequencing of human microglia expands the catalog of mRNA isoforms in this important cell type and assists with the interpretation of genetic associations with Alzheimer’s disease ...

"We found a way to exploit this flexibility by using forskolin to push these cells into a non-dividing, neuron-like or microglia-like state." Glioblastoma is notoriously difficult to treat ...

Tsukuba, Japan—The brains of mammals, including humans, not only contain neurons but also glial cells called microglia. Microglia modulate the immune response in the central nervous system ...

This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of amyloid-driven Alzheimer's disease. The evidence ...

Our research interest is to understand neuroinflammatory processes in neurodegenerative as well as infectious diseases. We aim to provide basic knowledge on how the brain's innate immune cells ...

Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation ...

Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we ...