A child with a rare genetic disorder — spinal muscular atrophy type I — was treated prenatally for the first time. Courtesy of Jakob Owens  via Unsplash During an amniocentesis test, a long, thin ...

Investigators in the laboratory of Gemma Carvill, Ph.D., assistant professor in the Ken and Ruth Davee Department of Neurology Division of Epilepsy/Clinical Neurophysiology, have discovered novel ...

The CBSE Class 12 Biology exam, set for March 25, 2025, demands more than memorization—it requires conceptual clarity, ...

RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to ...

The average size of this gene is approximately 1,300,000 base pairs (bp), while one of its messengers RNA (mRNAs) measures only 4,178 bp. Large Introns suggest the presence of transcriptional elements ...

After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut out and the coding portions are spliced back together. This process is ...

The segments in question are introns, short sequences of a subset of transfer RNAs, the RNA molecules that help guide assembly of amino acid chains during protein construction. These introns have ...

Surprisingly, co-transcriptional splicing kinetics did not correlate with final changes in splicing of polyadenylated RNA. This was particularly true for retained introns (RI). By using actinomycin D ...

We observe a subclass of circRNAs, coined DALI circRNAs, with distal inverted Alu elements and long flanking introns to be highly deregulated upon SFPQ knockdown. Moreover, SFPQ depletion leads to ...