Maternal stress is a major risk factor for preterm birth (PTB), with recent mouse studies highlighting the role of FKBP51 in stress-induced PTB. This study identifies the 15dPGJ2-mediated inhibition ...

Investigators in the laboratory of Gemma Carvill, Ph.D., assistant professor in the Ken and Ruth Davee Department of Neurology Division of Epilepsy/Clinical Neurophysiology, have discovered novel ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Novel patient-specific ASOs similarly reversed disease-associated phenotypes in cardiac organoids generated from two patients with DMD with a deep intronic variant in the DMD gene.

State Key Laboratory for Reliability and Intelligence of Electrical Equipment, Engineering Research Center of Ministry of Education for Intelligent Rehabilitation Device and Detection Technology, ...

Background: Porcine skeletal muscle development is pivotal for improving meat production. TP63, a transcription factor, regulates vital cellular processes, yet its role in skeletal muscle ...

We speculate that SFPQ plays an imperative role in splicing fidelity, a role that becomes increasingly important with intron length. With the persistent presence of intronic sequences, cryptic and ...