本研究针对白斑综合征病毒(WSSV)感染过程中内质网应激(ER stress)与未折叠蛋白反应(UPR)的调控机制展开。研究人员通过解析WSSV激活的PERK-eIF2α、IRE1和ATF6三条UPR通路，首次发现PERK-eIF2α通路通过磷酸化eIF2α抑制宿主全局蛋白翻译从而限制病毒感染，而IRE1和ATF6通路则 ...

研究发现结直肠癌中eIF2B复合物对维持p-eIF2α水平至关重要，敲低eIF2Bα或eIF2Bδ影响细胞存活，且APC缺陷型肿瘤依赖eIF2Bα，干扰该复合物与p-eIF2α的 ...

We show that colorectal cancer (CRC) with loss-of-function mutation in the APC tumor suppressor depends on an oncogenic translation program regulated by the ability to sense phosphorylated eIF2α ...

It is crucial to investigate the correlation between aging and the proteins eIF2β and eIF2α. Thank you so much for your review and comments. We included analyses of protein levels of eIF2α, eIF2β, and ...

Here, we reviewed the antecedents supporting PKR and the consequences of its activation as a key player in physiological conditions and its contribution in the neurodegenerative process involved in ...

We show that the circadian clock in the model fungus Neurospora crassa regulates rhythms in phosphorylation and activity of the conserved translation initiation factor eIF2α, with a peak in ...

Furthermore, the Ssd1-mediated reduction in protein synthesis during aging enabled optimization of the normal lifespan, because Ssd1 loss shortened lifespan while Ssd1 overexpression extended lifespan ...