Department of Medical Genetics and Microbiology and Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 Article Views ...

† Department of Molecular Life Science and Institute of Natural Sciences, Yeungnam University, Gyongsan 712-749, Korea ‡ Department of Food Science and Nutrition, Kyungpook National University, Daegu ...

本研究针对抗生素耐药性日益严峻的全球健康挑战，设计并合成了一系列靶向细菌二氢蝶酸合酶(DHPS)的新型噻吩并[2,3-d]嘧啶杂合化合物。通过生物电子等排体替换和间隔基修饰策略，研究人员发现化合物5b、14a和14b对金黄色葡萄球菌(S. aureus)表现出显著抗菌活性 ...