Whitehawk Therapeutics, Inc. , formerly known as Aadi Bioscience, Inc., an oncology therapeutics company applying advanced technologies to established tumor biology to efficiently deliver improved ...

BioCity Biopharmaceuticals and MSD have signed a clinical trial partnership agreement to assess BC3195 in conjunction with ...

Astrazeneca AB has synthesized antibody-drug conjugates comprising an antibody or antigen-binding fragment covalently linked to cytotoxic moieties through enzymatically cleavable linkers reported to ...

Continued progress with lead program, CX-2051 (EpCAM PROBODY® Topo-1 ADC), in Phase 1a study in advanced colorectal cancer with initial Phase ...

Enhertu improved overall survival versus chemotherapy in HER2-positive metastatic gastric cancer, prompting an interim ...

A series of protease-cleavable peptide probes was screened for the discrimination of PDAC samples versus healthy controls and ...

They screened a series of protease-cleavable peptide probes for the ability to differentiate patients with PDAC from healthy individuals and those with noncancer pancreatic disease. They ...

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China Research Center for Industries of the Future and Key Laboratory of Structural Biology of Zhejiang Province, School of ...

Paclitaxel, ifosfamide, cisplatin (TIP) in patients with advanced urethral adenocarcinoma: A single center, retrospective analysis. Adjuvant nivolumab (NIVO) vs placebo (PBO) for high-risk ...

Fmoc-NH-ethyl-SS-propionic acid 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联活性分子 (ADC)。 Fmoc-NH-ethyl-SS-propionic acid (CAS: 864235-83-6) ...

State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ...

To directly investigate the impact of HOIL1 cleavage activity on the inflammatory response, we employed a stable transduction system to express and directly compare non-cleavable HOIL1 with wild-type ...