本文聚焦细胞重编程用于改善与年龄相关细胞表型的研究。2006 年山中伸弥用 Oct4、Sox2、Klf4 和 c-Myc（OSKM）转录因子成功将小鼠体细胞重编程为诱导多能干细胞（iPSCs）。之后研究发现，在小鼠模型中诱导 OSKM 可延长寿命。靶向部分重编程意义重大，但用于人体 ...

胃癌是常见恶性肿瘤。研究人员开展 PRSS23 参与胃癌发生发展机制的研究，发现 PRSS23 通过调节 eIF4E-c-Myc 轴影响胃癌生长，高表达与不良预后相关。该轴有望成为胃癌治疗靶点，为攻克胃癌带来新希望。 胃癌是最常见的恶性肿瘤之一。此前研究表明，PRSS23 ...

OCT4 and c-MYC are widely accepted as CSC markers. In this study, we examined the immunohistochemical co-expression of c-MYC and OCT4 with Ki-67 in colorectal cancers (CRC) and the relationship ...

aUCL Cancer Institute, University College London, Department of Haematology, London WC1E 6DD, UK bUCL Great Ormond Street Institute of Child Health, Developmental Biology and Cancer, London, UK c-MYC ...

Methods: In this study, the expression levels of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, Sox2, and Klf4 were examined via immunohistochemistry in a panel of 71 benign ...

Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP28) has been implicated in tumourigenesis through its stabilization of the ...

Aging has implications for a wide range of diseases. Researchers have been looking for ways to halt the aging process for millennia, but such methods remain elusive. Scientists at Harvard Medical ...

Lu's work builds on the Nobel Prize winning discovery of Shinya Yamanaka, who identified the four transcription factors, Oct4, Sox2, Klf4, c-Myc, that could erase epigenetics markers on cells and ...

The viral supernatants were collected and filtered prior to infecting MEFs with polybrene (Sigma) as described (Esteban et al, 2010). Viruses containing Oct4, Sox2, Klf4, c‐Myc, and other factors were ...