CoA thioesters are valuable intermediates in numerous biosynthetic routes and metabolic processes. However, diversifying these compounds and their corresponding downstream products hinges on ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

The Acetyl CoA Carboxylase pipeline drugs market research report outlays comprehensive information on the Acetyl CoA Carboxylase targeted therapeutics, complete with analysis by indications, stage of ...

The Acetyl CoA Carboxylase 2 pipeline drugs market research report outlays comprehensive information on the Acetyl CoA Carboxylase 2 targeted therapeutics, complete with analysis by indications, stage ...

Insufficient acetyl-CoA derails the immune system's ability to protect the body. Until now, however, it was unclear exactly how immune cells maintained their acetyl-CoA reserves.

A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight ...

Department of Pediatrics Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States Microbiology/Immunology, Carver College of Medicine ...

13 C-acetyl-CoA and 13 C-incorporated TCA cycle metabolites such as citrate, aconitate, isocitrate, succinate, fumarate, and malate were dramatically increased in the brain (Figure 8A–G), but ...

Mechanistically, ACOT 12&8 are dramatically upregulated in liver to convert FFA-derived acetyl-CoA to acetate and CoA. This conversion not only provides large amount of acetate which fuels brain ...

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