Lentiviral vectors have great potential as gene therapy vectors. 1 2 3 For clinical studies and other gene therapy applications, it is essential to accurately determine the functional titers of ...

To confirm liver-specific expression from the rAAV-LSP-βgb-hFIX-WPRE vector construct, FIX levels were measured in vitro following infection of a variety of cell types (Figure 3). Transgene ...

In this phase 1–2 trial, we infused an investigational adeno-associated viral (AAV) vector (SPK-8011) for hepatocyte expression of factor VIII in 18 men with hemophilia A. Four dose cohorts were ...

Retroviral vectors that are both non-replicating and non-integrating represent a novel and attractive tool that has potential advantages for gene delivery therapy, immunotherapy, and vaccinology.

The Baculovirus Expression Vector System (BEVS) is used to produce recombinant proteins. This is very useful in regards to virology studies and biotechnology applications. Baculovirus on ice ready ...

An increase in serum choline levels to predict progression-free survival (PFS) in patients (pts) with advanced cancers receiving pembrolizumab. A phase I, dose-escalation study of ADG106, a fully ...