Lentiviral vectors have great potential as gene therapy vectors. 1 2 3 For clinical studies and other gene therapy applications, it is essential to accurately determine the functional titers of ...

Wacker and Expression Manufacturing want to offer clients with an end-to-end, optimized solution for viral vector development ...

This study demonstrates that the coexpression of mCTLA4Ig and dystrophin in skeletal muscle provided by HC-Ad vector-mediated gene transfer can provide stable expression of dystrophin in ...

Retroviral vectors that are both non-replicating and non-integrating represent a novel and attractive tool that has potential advantages for gene delivery therapy, immunotherapy, and vaccinology.

In this phase 1–2 trial, we infused an investigational adeno-associated viral (AAV) vector (SPK-8011) for hepatocyte expression of factor VIII in 18 men with hemophilia A. Four dose cohorts were ...

This novel vector technology with its persistent payload expression offers certain advantages over other gene delivery systems (DNA, mRNA, viral) for transient protein expression and use in gene ...

An increase in serum choline levels to predict progression-free survival (PFS) in patients (pts) with advanced cancers receiving pembrolizumab. A phase I, dose-escalation study of ADG106, a fully ...

The Baculovirus Expression Vector System (BEVS) is used to produce recombinant proteins. This is very useful in regards to virology studies and biotechnology applications. Baculovirus on ice ready ...

Data highlights advantages of single, non-replicative HSV-1 (nrHSV-1) vector hosting two transgenes with independent expression kineticsVectors also show high transduction rate of neurons in the CNS ...

Our vector technology uniquely enables the delivered RNA payload to be persistently expressed for days without integrating into the cellular genomes. This improves upon the persistence of nonviral ...