Here, we present a replication-competent Sindbis viral vector that has an hsvtk suicide gene incorporated into ns3, ... Wild-type Sindbis virus RNA genome has two major groups of genes: ...

Researchers have made a significant new discovery about RNA (ribonucleic acid) viruses and how they replicate themselves. Certain RNA viruses -- poliovirus, hepatitis C virus and coxsackievirus ...

Moreover, most regulatory agencies require that vector manufacturing lots intended for use in humans must be tested for replication competent viruses, which adds an additional complication to the ...

How the influenza virus achieves efficient viral RNA replication. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 10 / 191003140953.htm ...

The coronavirus that causes COVID-19, SARS-CoV-2, is known as a positive-strand RNA virus because of the way it stores and makes copies of its genetic material. Many other important pathogens such as ...

The viral RNA replication protein that forms the crown is an extremely large, multi-domain, multi-functional protein, nearly 1000 amino acids in size.

In a recent study posted to bioRxiv*, researchers evaluated the early replication kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Visualization of early RNA ...

“This protein has a flexible region, can form oligomers, binds RNA, the norovirus’s genetic material, and plays an essential role during viral replication making copies of the viral RNA. All these ...

Development of an RNA virus vector for non-transgenic genome editing in tobacco and generation of Berberine Bridge Enzyme-Like mutants with reduced nicotine content https://link.springer.com ...

Hitchcock notes that as viral vector manufacturing processes are scaled, the likelihood of the generation of replication competent viruses increases, which poses challenges for purification. Improving ...

Dublin, April 05, 2024 (GLOBE NEWSWIRE) -- The "Viral Vector and Plasmid DNA: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering. The global market for ...