These vector particles, without an RNA genome encoding structural proteins ... A safety mechanism should ideally be directly linked with the viral replication machinery to tightly control its ...

The coronavirus that causes COVID-19, SARS-CoV-2, is known as a positive-strand RNA virus because of the way it stores and makes copies of its genetic material. Many other important pathogens such as ...

Moreover, most regulatory agencies require that vector manufacturing lots intended for use in humans must be tested for replication competent viruses, which adds an additional complication to the ...

Researchers have made a significant new discovery about RNA (ribonucleic acid) viruses and how they replicate themselves. Certain RNA viruses -- poliovirus, hepatitis C virus and coxsackievirus ...

How the influenza virus achieves efficient viral RNA replication. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 10 / 191003140953.htm ...

Within an infected cell, viral RNA replication occurs at modified cellular membranes, often in association with spherules, virus-induced vesicles approximately 50–100 nanometers in size.

The viral RNA replication protein that forms the crown is an extremely large, multi-domain, multi-functional protein, nearly 1000 amino acids in size.

In a recent study posted to bioRxiv*, researchers evaluated the early replication kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Visualization of early RNA ...

The authors developed a non-transgenic genome editing approach in tobacco by delivering CRISPR/Cas9 with an engineered eggplant mottled dwarf virus (EMDV) vector, a negative-strand RNA virus ...

It is also why developing highly effective vaccines against RNA viruses remains challenging. A second, indirect consequence of the low-fidelity replication process is the small size of the viral ...

The lentiviral vector, modified from HIV-1, was known to infect non-dividing cells (3). A lentiviral vector system was then developed in an attempt to find a viral vector system that could achieve ...