产品描述：Valproic acid (VPA) 是一种 HDAC 抑制剂，IC50 值为 0.5-2 mM，抑制 HDAC1 的活性 (IC50=0.4 mM)，同时可诱导 HDAC2 的降解。Valproic acid 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍和偏头痛等的研究。Valproic acid 通过上调 ...

The combination of sorafenib tosylate, valproic acid, and sildenafil demonstrated activity in a phase 2 trial of patients with high-grade glioma. Researchers reported results from the trial in a ...

After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepi-leptic ... In this review, we aim to highlight, with a translational intent, the ...

Valproic Acid is an anticonvulsant, prescribed for epilepsy, bipolar disorder, and rarely for depression. It works by increasing the amount of a certain chemical in the brain.

Are you taking Valproic acid? Are you aware of the dangers of combining Valproic acid with alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and ...

Valproic acid dissociates to form valproate ... types of seizures that are characterized by unique molecular events. Gamma-aminobutyric acid (GABA) is an important neurotransmitter that is widely ...

Explain what to expect during the test. If your child is anxious about it, work together on ways to stay calm. Valproic (val-PRO-ik) acid is an anticonvulsant medicine that doctors often prescribe to ...

Valproic acid (VPA), formally 2-propylpentanoic acid, is a low–molecular weight branched-chain fatty acid ... even though an inspection of its structure shows that that cannot be true. VPA is widely ...

VPA, valproic acid; EMT, epithelial–mesenchymal transition; MMP2/9, matrix metalloproteinase 2/9; AIF, apoptosis-inducing factor; VEGF, vascular endothelial growth factor. Figure 2 VPA exerted ...