In the valproate treated group, the latency of epileptic episodes (SD) was significantly higher than the PTZ alone group, 1095.71 (49.56) vs 55.00 (1.80) sec, respectively.

Valproic acid dissociates to form valproate ions in the body, which has numerous effects on the neuronal tissue in the brain. This accounts for its broad clinical activity and use in several ...

In addition to the teratogenic effects of valproate, maternal use of the drug during pregnancy has been associated with decreased neurocognitive function in children, 4-18 and increased risks of ...

Use of lithium vs. valproate as a prophylactic treatment may be associated with adverse kidney outcomes, including AKI, according to recently published research. A team led by Alessandro Bosi, MSc ...

The combination of valproate, given as a mood stabilizer, with olanzapine was chosen to reduce the required dose of an antipsychotic drug and thus help prevent adverse effects that could lead to ...