Nevertheless, it has been demonstrated that Akt and E3 ligase MDM2 form a complex with AR and promote phosphorylation-dependent AR ubiquitination, resulting in AR degradation by the proteasome.

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts ...

By influencing these pathways, ubiquitination emerges as a potentially powerful therapeutic target to disrupt the aggressive nature of CSCs. The involvement of the Ub-proteasome system (UPS ...

Thus, in the absence of NGLY1, Nrf1 is detected as a stable ubiquitinated protein in the cytosol, and this ubiquitination prevents Nrf1 from nuclear transport. The proteasome is a major player in ...

By influencing these pathways, ubiquitination emerges as a potentially powerful therapeutic target to disrupt the aggressive nature of CSCs. The involvement of the Ub-proteasome system (UPS ...

The data suggest that there may be general and specific de-ubiquitination events taking place at synaptosomes. These are most likely unrelated to removal of ubiquitin-tagged proteins by the proteasome ...

The proteasome, being the final destination for proteins tagged for proteolytic degradation, is intimately associated with the ubiquitination pathway, one which flags proteins with strings of the ...

A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, "Restoring our ubiquitination ... Center discuss the ubiquitin-proteasome system (UPS), which is usually ...

the researchers found that aging causes a general loss of ubiquitination. This is caused by the enzymes that remove ubiquitin from proteins become more active during aging. Normally, ubiquitinated ...

"Our results show that a PUB8-mediated ubiquitination proteasome pathway participates in regulating ABA signaling to precisely control early seedling establishment after seed germination," said Hu ...