The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Cephalon, Inc., 145 Brandywine Parkway, West Chester, Pennsylvania 19380, and Cell Therapeutics Europe S.r.l., Via L. Ariosto, 23, I-20091 Bresso, Italy Article Views are the COUNTER-compliant sum of ...

Figure 1. The Ubiquitin Proteasome System. The proteasome degradation of specific substrates and misfolded proteins occurs through an enzymatic cascade of ubiquitination. The human genome encodes ...

Find more information on the Altmetric Attention Score and how the score is calculated. The ubiquitin proteasome system is an attractive pharmacological target for the treatment of cancer. The ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

We have tested whether, as in other cases, retro‐translocation requires poly‐ubiquitination. We show that an A1 chain mutant that lacks lysines and has a blocked N‐terminus, and therefore cannot be ...