Figure 3. Hypothetical model of Ubiquitin Proteasome System (UPS) dysfunction after ischemia-reperfusion injury. Ischemia-reperfusion injury impairs proteasome function through 3 main mechanisms.

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Figure 3. Hypothetical model of Ubiquitin Proteasome System (UPS) dysfunction after ischemia-reperfusion injury. Ischemia-reperfusion injury impairs proteasome function through 3 main mechanisms.

aMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, VIC, Australia bMelbourne Dementia Research Centre, Florey Institute of ...

Our major objectives are to understand the role of the ubiquitin/proteasome system in the development of neurodegenerative diseases and cancer and to explore the therapeutic potential of modifiers of ...

Data accompanying the manuscript "Lysine-deficient proteome can be regulated through non-canonical ubiquitination and ubiquitin-independent proteasomal degradation" by Szulc et al., 2023.

It has been previously shown that the ubiquitin-proteasome system coordinates cellular responses to repair the UV-induced DNA damage. However, the detailed mechanism behind this had not been ...

This platform uses small molecules to reprogram the Ubiquitin Ligase-Proteasome system to target important intracellular proteins that cannot be inhibited by conventional small molecule approaches.

1 Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Collaborative Innovation Center for Brain Science, Xiamen University ...