The liver exhibits metabolic zonation, with gene expression and metabolic functions distributed across specific zones along ...

The Ubiquitin Proteasome System. The proteasome degradation of specific substrates and ... The COP9 signalosome complex regulates the CRL ligase activity via removing NEDD8 from NEDD8-conjugated ...

Here, we will review principles of ubiquitin‐dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.

Comparison with surface features of ubiquitin and ubiquitin homologs SUMO-1, RUB-1 and NEDD8 suggest how Nature has utilized this single fold to incorporate similar chemistry into a broad array of ...

Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan ...

NEDD8/Rub1 is a ubiquitin (Ub)‐like post‐translational modifier that is covalently linked to cullin (Cul)‐family proteins in a manner analogous to ubiquitylation. NEDD8 is known to enhance the ...