They possess a distinct primary sequence but share characteristic ... and mammalian cells point out another role of ubiquitin and Ubls in DNA repair, apoptosis and cell-cycle control.

such as gene transcription and immune function. These breakthrough discoveries earned them the Nobel Prize in Chemistry in 2004. Through these steps, the ubiquitin molecule forms an isopeptide ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through adenylation ... These studies revealed structural determinants for recognition of consensus SUMO modification ...

Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to ...

The ubiquitin gene profile helped identify the specific biological characteristics and clinical prognosis linked to these patients’ organs. A comprehensive analysis based on biocomputational and ...

Using a metric derived from mRNA codon composition, they found out how gene sequence choice can predict different aspects of protein synthesis, such as protein production efficiency. The study ...

Scientists who disrupted one type of the gene ubiquitin (Ubb) in mice observed neuronal death in the hypothalamus, impaired control of energy balance and adult-onset obesity in the rodents.